Botox® & Xeomin® in Pittsburgh, PA
Pittsburgh’s North Hills · Botox® and Xeomin® Neuromodulators
Botox® and Xeomin® are injectable neuromodulators that soften the dynamic lines created by everyday expression: frowning, squinting, and raising the brows. At Aetheria both are dosed conservatively and placed precisely, with the goal of a refreshed look that still moves like you.

What Are Neuromodulators?
Botox® and Xeomin® are both purified botulinum toxin type A. They share the same active mechanism and treat the same lines. The practical difference is formulation, and that is where the clinical choice between them comes in. Most treatments take about 10 to 20 minutes, with visible softening in a few days and full results around two weeks.
A neuromodulator should soften the lines while letting your expressions stay yours. Our approach is conservative and precise, aiming for refreshed, natural-looking results.
Botox® Treatment Overview
Botox® is the most recognized neuromodulator and a trusted treatment for softening dynamic facial lines, the fine to moderate wrinkles that form from repeated movement such as frowning, squinting, or raising the brows. Common treatment areas include frown lines (the 11s), crow’s feet, and forehead lines, restoring a rested, refreshed appearance without changing your natural expression.
Most treatments take about 10 to 20 minutes with little to no downtime. Many patients notice softening within a few days, with full results around two weeks, lasting three to four months depending on anatomy, lifestyle, and individual response.
About Xeomin®
Xeomin® is a purified form of botulinum toxin type A that relaxes the targeted muscles responsible for dynamic lines. Like Botox®, it smooths frown lines, forehead lines, and crow’s feet with results that look natural and keep your expressions intact.
Its uncomplexed formulation, free of accessory proteins and preservatives, is one reason many of our patients prefer it, particularly those who treat regularly and want a clean, simplified neuromodulator. Sessions take 10 to 20 minutes with minimal downtime. Softening begins within several days, with full effect around two weeks, lasting approximately three to four months.
Botox® vs Xeomin®: Which Is Right for You?
Botox and Xeomin treat the same dynamic lines and both produce natural results. The practical difference is formulation. Xeomin is a purified, uncomplexed formulation with no accessory proteins, which is one reason we often reach for it, especially for patients who treat regularly. Here is how they compare side by side.
| Factor | Botox® | Xeomin® |
|---|---|---|
| Active ingredient | Botulinum toxin type A | Botulinum toxin type A (incobotulinumtoxinA) |
| Formulation | Contains accessory complexing proteins | Uncomplexed, no accessory proteins, preservative free |
| Smooths frown lines, forehead lines, crow’s feet | Yes | Yes |
| Lip flip and bunny lines | Yes | Yes |
| Platysmal (neck) bands | Yes | Yes |
| Onset | 3 to 7 days | 3 to 7 days |
| Full effect | Around 2 weeks | Around 2 weeks |
| Typical duration | 3 to 4 months | 3 to 4 months |
| Designed to limit resistance over repeat treatment | Not applicable | Yes |
| Natural-looking result | Yes | Yes |
How Botox® and Xeomin® Work
A neuromodulator follows a predictable timeline. Here is what to expect after treatment.
Day 0: Treatment
Melissa maps your dynamic lines and places a conservative dose into the targeted muscles. The visit takes about 10 to 20 minutes with little to no downtime. You can return to most normal activity the same day.
Days 4 to 7: Onset
Softening begins as the neuromodulator takes effect on the treated muscles. Lines start to relax. This early change is partial, and the result is still developing, so we do not assess the final outcome yet.
Day 14: Full Effect
The result reaches its peak around two weeks. Forehead lines, frown lines, and crow’s feet appear smoother while your natural expression stays intact. This is when we evaluate and fine-tune at follow-up if needed.
Months 3 to 4: Maintenance
The effect gradually fades as muscle movement returns. Most patients return every three to four months. We track your individual duration across visits and adjust the maintenance interval to your response.
What Botox® and Xeomin® Treat
Neuromodulators are most effective on dynamic lines, the ones created by repeated muscle movement. Common treatment areas include the following.
Frown Lines (the 11s)
Softens the vertical lines between the brows that deepen with frowning and concentration.
Forehead Lines
Relaxes the horizontal lines that form across the forehead from raising the brows.
Crow’s Feet
Smooths the fine lines that fan out from the corners of the eyes when you smile or squint.
Bunny Lines
Eases the diagonal creases that appear along the sides of the nose with expression.
Lip Flip
A small dose relaxes the upper lip border for a subtly fuller, more relaxed smile.
Platysmal Bands
Softens the vertical neck bands, sometimes called tech neck, for a smoother neckline.
Is Botox® or Xeomin® Right For You?
A neuromodulator may be a fit if you want to soften dynamic lines while keeping a natural, expressive look. Most patients we treat with Botox or Xeomin share several of these characteristics:
- Notice forehead lines, frown lines, or crow’s feet that deepen with expression
- Prefer a refreshed, natural-looking result built gradually
- Prefer to start conservatively and build to the right dose over time
- Are not pregnant or breastfeeding
- Do not have a neuromuscular condition that a neuromodulator can affect
- Want a provider who will tell you honestly when a different treatment fits better
If you are unsure whether Botox or Xeomin fits your goals, the consultation is where Melissa determines which neuromodulator, dose, and plan is the right clinical approach for you.
Why Aetheria for Botox® and Xeomin®
The most common cause of an overdone neuromodulator result is moving too aggressively before knowing how your muscles respond. A conservative, considered approach is not a marketing line. It is the right clinical approach, and it is how every treatment is dosed at Aetheria.
Every Botox and Xeomin treatment is performed by Melissa Kolowitz, PA-C. Always Melissa. Same provider, same protocols, same clinical eye every visit. The plan you agree on at consultation is the one Melissa delivers.
- Conservative first dose. We start measured so we can see how you respond before adding more at follow-up.
- Clinical experience first. Twenty years of clinical medicine inform every dosing and placement decision.
- Two-week follow-up. We assess your result at peak and fine-tune if needed.
- Honest fit assessment. If a filler or another treatment is the better answer for your concern, Melissa will tell you.
Your Botox® and Xeomin® Visit
From first conversation to follow-up, here is how a neuromodulator treatment works at Aetheria.
Consultation
Melissa assesses your facial movement, skin, and goals, then walks through whether Botox or Xeomin and what dose fits. About 30 minutes, with no pressure to treat the same day.
Customized Plan
Together you decide which neuromodulator and which areas to treat. The plan reflects your anatomy and how subtle or noticeable you want the result to be.
Treatment
The injections take only minutes, with minimal discomfort and little to no downtime. You can return to most normal activity right away, following a few simple aftercare guidelines.
Results and Follow-Up
Softening begins within days and peaks around two weeks. We schedule a follow-up to assess your result and fine-tune the plan for next time.
Common Questions About Botox® and Xeomin®
For most patients the effect lasts three to four months, though it varies with metabolism, the area treated, dose, and treatment history. The first treatment often wears off slightly faster than later ones because the muscle is still learning the pattern. We track your individual duration across visits and adjust your maintenance interval so your results stay consistent. Individual results vary.
Onset usually begins between day four and day seven after treatment, when you notice the first softening of the treated lines. The effect develops gradually from there and reaches its peak around day fourteen, so we do not judge the final result before then. Early change is partial, and that is expected. If anything needs fine-tuning, your two-week follow-up is when Melissa evaluates the outcome and makes any small adjustment to placement or dose.
Both are purified botulinum toxin type A and treat the same dynamic lines. The difference is formulation. Xeomin is uncomplexed, with no accessory proteins and no preservative, which is one reason we often choose it for patients who treat regularly. Botox is the most recognized option and performs reliably. At your consultation Melissa recommends the one that best fits your history and goals.
Both have long safety records when administered by a trained clinician. The most common effects are mild and temporary: small bruising, redness, or tenderness at the injection sites, and occasionally a short-lived headache. Less common effects relate to placement, which is why precise, conservative dosing matters. We review your history at consultation to confirm a neuromodulator is appropriate for you.
Yes, and we treat first-time patients conservatively by design. We would rather start measured and add a little more at your two-week follow-up than overtreat on day one. That approach keeps your result natural while you learn how your muscles respond. If a neuromodulator is not the right fit for your concern, Melissa will tell you and suggest a better option.
What Patients Say
EXCELLENT Based on 24 reviews Posted on BethanyTrustindex verifies that the original source of the review is Google. I recently had my 1st microneedling treatment at Aetheria Aesthetics & Wellness, which is a boutique medical spa in Pittsburgh, PA. Melissa, the owner, is a PA and has over 20 years of surgical care experience. She's very friendly and good at explaining the procedure step by step. When you go, she'll do a consultation with you where you'll discuss your skin concerns and goals. She's honest and will give you good advice. She made the treatment easy. She told me what to expect afterwards for the next few days and how to care for my skin while it was healing. I'm happy with my results and will go to her for other treatments. She also offers a lot of other treatments like Botox, filler, weight management, laser, and more. I think you'll like her and will be happy with your results!Posted on Stephanie MillerTrustindex verifies that the original source of the review is Google. I have really oily skin and redness, I kept following all these skincare routines off tiktok but decided it was time to really get advice from a professional. Melissa seriously knew exactly what my skin needed. She picked out a chemical peel that was just right for my skin concerns, she explained to me everything I needed to do moving forward. I really felt heard and when I left I already saw a huge difference in my skin. It's been a week later and I am seriously obsessed with the results!! I am so grateful!Posted on Jessica MillerTrustindex verifies that the original source of the review is Google. I had a wonderful experience at Aetheria Aesthetics for my ZO peel. Melissa was absolutely fantastic—and so incredibly sweet. She took the time to really understand my skin, my goals, and my concerns before making recommendations. I never felt rushed, and I truly appreciated how thoughtful and knowledgeable she was in explaining the process and giving personalized advice. Highly recommend Aetheria Aesthetics and Melissa if you’re looking for expert care with a genuinely kind touch!Posted on Kianna BrunnerTrustindex verifies that the original source of the review is Google. I had such a great experience getting Botox with Melissa at Aetheria Aesthetics! She is seriously the sweetest and makes you feel comfortable right away. She’s also super knowledgeable and really strategic with where she places the injections, which I appreciated a lot. The whole process was way more painless than I expected, and she has such a gentle technique. My results turned out AMAZING — super natural and exactly what I was hoping for. Highly recommend Melissa if you’re thinking about Botox. She’s the best! ✨Posted on brittany pentTrustindex verifies that the original source of the review is Google. I absolutely adore Melissa! Her space is cute and clean. I went to her for Botox and could not be more thrilled with my results. Melissa is so knowledgeable and thorough. Everything was so well explained to me. I am sooooo happy that she does a two week follow up for Botox because my before and after pictures are MIND BLOWING!!!! I could physically see a difference in the mirror but then seeing the before pictures next to my current photo…I was shocked! She is so gifted. I am sooooo happy I found her !Posted on Rachelle FarquharTrustindex verifies that the original source of the review is Google. Very professional and good experience! Reasonably priced and realistic!Posted on Dakota PetersonTrustindex verifies that the original source of the review is Google. I had an incredible experience with Melissa! She’s the absolute SWEETEST! I got Botox and she went over what the products were and the science behind them, making sure I knew what I was putting in my body. Her suite is so cute and well done I loved everything about it! 1000000/10💕Posted on Aaryn HuntTrustindex verifies that the original source of the review is Google. I had a great experience with Melissa today! I didn’t realize that the Sola suites moved to the mall, I love the location. Her suite is very clean and intimate. She is knowledgeable and skilled with a medical background as a PA and that gave me full confidence in her doing my laser hair removal treatment. I’ll definitely be back!Posted on Brooke PostlerTrustindex verifies that the original source of the review is Google. I cannot express how amazing Melissa is! I left there after getting the ZO accelerated peel feeling so excited to have finally met someone who listened to my concerns and created a plan for me that is backed by science. Melissa took the time to sit with me and fully explain each product and each step of the experience. I will recommend her to everyone!Posted on Madi ShickTrustindex verifies that the original source of the review is Google. This experience has completely changed my skin. Melissa did an amazing job making me feel comfortable about microneedling throughout the entire session. I cannot recommend her services enough. With her years of experience, you’ll not only leave with a glow, but also a ton of knowledge about your skin.
Pair Botox® and Xeomin® With
Neuromodulators work beautifully alongside other treatments at Aetheria. Here are the most common pairings.
Dermal Fillers
For volume loss and deeper folds, fillers restore structure where a neuromodulator cannot. The two pair well for full-face balance.
Sculptra
A collagen biostimulator that rebuilds volume gradually over months, for patients who want natural, longer-lasting structure.
Full Aesthetic Menu
See every injectable and skin treatment available at Aetheria.
Visit Aetheria in Pittsburgh’s North Hills
Botox and Xeomin at Aetheria are by consultation. We serve patients across Pittsburgh’s North Hills, including Ross Township, Wexford, Cranberry Township, Sewickley, and Mars. Book online or call to schedule a clinical assessment with Melissa Kolowitz, PA-C.
Sola Salon, 1000 Ross Park Mall Dr Suite 4B
Pittsburgh, PA 15237
(412) 385-3191 ·
[email protected]